The vibration of the body to produce a higher percentage of macrophages and prevent diabetes

Obesity has been identified as one of the main risk factors in the development of type 2 diabetes. On the other hand, it has also been observed that alterations in the intestinal microbiota played a role in the appearance of both obesity and type 2 diabetes Does this mean that a modification of the intestinal microbiota could contribute to cause, prevent or manage type 2 diabetes?

For the first time, it has been described how regular use of whole body vibration can create a healthier mixture of the microbiota by producing a higher percentage of macrophages, cells that can promote or prevent inflammation, which suppress rather than promote.

Connections with the microbiota

At least in mice, researchers at the Georgia School of Medicine and the Georgia School of Dentistry at the University of Augusta have shown that the vibration of the whole body alters the microbiome, a collection of microorganisms in and on our body, which help protect us from invaders and, in the intestine, help us digest food.

The changes they saw included increasing levels of a bacterium that produces short-chain fatty acids, which can help the body use glucose better. The body uses glucose as fuel, but at high levels it promotes inflammation, insensitivity to insulin and, ultimately, can cause diabetes.

While there were other changes, the most interesting thing they documented was the increase of 17 times in this bacterium called Ready, an intestinal bacteria that does not usually have a high supply, but it is known that it is competent in the production of short chain fatty acids which, in turn, is very good for reducing inflammation in the intestine.

Ready, which helps to ferment our food without producing alcohol, generally improves the metabolic state of our intestines and makes us more competent in the use of the glucose we consume for energy.

When they saw this, the researchers thought that administering a dose of the bacteria, as it would do with a medication, might work just as well. When Alistipes increased, the use of glucose and the macrophage mixture also improved.

Macrophages, which promote inflammation, called M1, and suppress inflammation, called M2, play an important role in regulating the inflammatory response. The inflammatory state of macrophages also influences the intestinal microbiome and vice versa.

Our microbiome, like a saucepan, it's layered and one way the whole body's vibration can work is by rearranging those layers, but nobody is sure how the whole body vibration works in this or other scenarios. But it seems to help address a key concern in diabetes and many common diseases: inflammation. While acute inflammation helps us fight disease, chronic inflammation helps start and maintain a variety of diseases, from cardiovascular problems to cancer and diabetes.

With the increase in obesity rates caused by inflammation and related type 2 diabetes, new therapies are needed that can directly help avoid health consequences. They add that while more work is needed, whole body vibration could be a widely applicable and generally safe approach to use.

Much more research is needed to know both the effects and the medical potential of vibration in regards to our gastrointestinal bacteria, but it is an undeniable first step to discover new treatments capable of effectively fighting against type 2 diabetes, inflammation and obesity.

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